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| AAI has designed a new generation of low temperature reactor systems to carry out exothermic reactions down to -100 °C while removing energy at those temperatures. This second generation reaction system employs liquid nitrogen (LIN, boiling point down to -195 °C) to deliver refrigeration to the reactor and is the key element in the new chemistry to produce LIPITOR, a statin-formulated cholesterol lowering drug. A 2000-gallon system has been in operation since July 1996. Two 2000-gallon systems have been in operation since 1998, and the latest was brought online in 2001. AAI's patented reactors can maintain the same uniformity and performance at ANY configuration and ANY batch size, eliminating your scale-up concerns. Bulk cooling rates up to 2 C/min can be maintained, along with tight axial and radial uniformity. The high cooling capacity allows tight control over high exotherms. This results in yields 5 times that of a conventional low temperature reactor, with unparalleled product uniformity and low VOC emissions. Highly exothermic reactions can be maintained from -200C to +300C setpoints. We have successfully installed small pilot reactors to full production reactors, all with equal gradient, uniformity and cooling rate performance. |
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| CASE STUDY: This reactor system was started up in the summer of 2001, with continuous reliable operation since then. It was installed at our Client's facility in Scotland as part of their phase I production of the active ingredients for CRESTOR. The reactor system was designed for cooling an 8000-liter batch of THF at 1 C/min, with a batch warm-up rate of 0.5 C/min. Operation to date has shown product yields that have matched and beat the highest laboratory yields, which demonstrates again that the AAI reactor can eliminate any scale-up concerns. It features an integral Siemens s7 PLC control system, Challenger HMI, heating module, low VOCs and improved coolant management equipment, as well as algorithms which virtually eliminate critical cooling control modulations: the key to successful management of low temperature reactors. Download our brochure or contact us to find out more about integrated reactor systems. |
| COPYRIGHT ARENCIBIA ASSOCIATES, INC. AND/OR ARENCIBIA ASSOCIATES EQUIPMENT SERVICES, INC. |